APL:：美科學(xué)家開發(fā)超靈敏生物傳感器

Taking whispering gallery-mode single virus detection and sizing to the limit

V. R. Dantham1, S. Holler1,2, V. Kolchenko3, Z. Wan4, and S. Arnold1 iso

We report the label-free detection and sizing by a microcavity of the smallest inpidual RNA virus, MS2, with a mass only ～1% of InfluenzaA (6 vs. 512 ag). Although detection of such a small bio-nano-particle has been beyond the reach of a bare spherical microcavity, it was accomplished with ease (S/N?=?8, Q?=?4?×?105) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer, providing an enhancement of ～70×, in agreement with theory. Unique wavelength shift statistics are recorded consistent with an ultra-uniform genetically programmed substance that is drawn to the plasmonic hot spots by light-forces.

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